| Matches Involving Chicago Fire |
| |
| 14 Apr 2010 | | (H) vs. Columbus Crew | W | 2 - 0 | MLS |
| 17 Apr 2010 | | (A) vs. New England | W | 0 - 1 | MLS |
| 24 Apr 2010 | | (H) vs. FC Dallas | W | 2 - 1 | MLS |
| 1 May 2010 | | (A) vs. Colorado Rapids | W | 0 - 1 | MLS |
| 8 May 2010 | | (H) vs. Chivas USA | W | 2 - 0 | MLS |
| 15 May 2010 | | (A) vs. Kansas City | D | 0 - 0 | MLS |
| 22 May 2010 | | (A) vs. D.C. United | W | 2 - 4 | MLS |
| 29 May 2010 | | (H) vs. NY/NJ Metrostars | W | 3 - 0 | MLS |
| 5 Jun 2010 | | (A) vs. Real Salt Lake | D | 1 - 1 | MLS |
| 9 Jun 2010 | | (H) vs. San Jose | W | 2 - 0 | MLS |
| 12 Jun 2010 | | (A) vs. Los Angeles | W | 0 - 2 | MLS |
| 16 Jun 2010 | | (H) vs. D.C. United | W | 3 - 0 | MLS |
| 19 Jun 2010 | | (H) vs. New England | W | 1 - 0 | MLS |
| 23 Jun 2010 | | (A) vs. Columbus Crew | D | 1 - 1 | MLS |
| 26 Jun 2010 | | (A) vs. Los Angeles | W | 1 - 2 | MLS Open Cup - Round 1 |
| 3 Jul 2010 | | (H) vs. Real Salt Lake | W | 4 - 2 | MLS |
| 10 Jul 2010 | | (A) vs. NY/NJ Metrostars | | | MLS |
| 17 Jul 2010 | | (A) vs. Chivas USA | | | MLS |
| 24 Jul 2010 | | (A) vs. San Jose | | | MLS Open Cup - Quarter-Final |
| 31 Jul 2010 | | (H) vs. Colorado Rapids | | | MLS |
| 4 Aug 2010 | | (A) vs. San Jose | | | MLS |
| 7 Aug 2010 | | (A) vs. FC Dallas | | | MLS |
| 11 Aug 2010 | | (H) vs. Kansas City | | | MLS |
| 14 Aug 2010 | | (H) vs. Los Angeles | | | MLS |
| 18 Aug 2010 | | (A) vs. D.C. United | | | MLS |
| 21 Aug 2010 | | (A) vs. FC Dallas or Kansas City | | | MLS Open Cup - Semi-Final |
| 25 Aug 2010 | | (H) vs. Columbus Crew | | | MLS |
| 28 Aug 2010 | | (A) vs. Los Angeles | | | MLS |
| 4 Sep 2010 | | (A) vs. Real Salt Lake | | | MLS |
| 11 Sep 2010 | | (H) vs. NY/NJ Metrostars | | | MLS |
| 18 Sep 2010 | | (H) vs. Chivas USA | | | MLS |
| 25 Sep 2010 | | (A) vs. [TBD] | | | MLS Open Cup - Final |
| 2 Oct 2010 | | (A) vs. Colorado Rapids | | | MLS |
| 6 Oct 2010 | | (H) vs. San Jose | | | MLS |
| 9 Oct 2010 | | (H) vs. FC Dallas | | | MLS |
| 13 Oct 2010 | | (A) vs. Kansas City | | | MLS |
| 16 Oct 2010 | | (A) vs. New England | | | MLS |
| 27 Oct 2010 | | (?) vs. [TBD] | | | MLS Playoffs - Quarter-Final, Leg 1 |
| 30 Oct 2010 | | (?) vs. [TBD] | | | MLS Playoffs - Quarter-Final, Leg 2 |
| 6 Nov 2010 | | (?) vs. [TBD] | | | MLS Playoffs - Semi-Final |
| 13 Nov 2010 | | (?) vs. [TBD] | | | MLS Playoffs - Final |